Active Pharmaceutical Ingredients Tetrahydrozoline hydrochloride

What is Tetrahydrozoline hydrochloride ?

Tetrahydrozoline Hydrochloride is the hydrochloride salt form of tetrahydrozoline, an imidazole derivative with sympathomimetic property. Applied locally to the eye or nose, tetrahydrozoline binds to and activates alpha-adrenergic receptors, resulting in vasoconstriction and decreased nasal and ophthalmic congestion.

Tetrahydrozoline hydrochloride is the hydrochloride salt of tetryzoline. It is used as a nasal decongestant. It has a role as a sympathomimetic agent, a vasoconstrictor agent and a nasal decongestant. It contains a tetryzoline

Tetrahydrozoline hydrochloride is a medication used to relieve redness in the eyes caused by minor eye irritations (such as smog, swimming, dust, or smoke). It works by narrowing swollen blood vessels in the eyes to reduce eye redness. It is also used as a decongestant for nasal congestion. Tetrahydrozoline hydrochloride is available in over-the-counter topical ocular and nasal formulations.

Product Description

Classification Type Tetrahydrozoline hydrochloride
CAS NO. 522-48-5 Other names Tetrahydrozoline
MF C13H17CLN2 EINECS NO. 232-536-8
Place of origin China Grade standard   USP grade
Purity 99% Appearance White  powder
HS CODE 2934990002 packing 25kg/drum
Shelf life 3 MOQ
Application RAw  Material

描述

Specification

Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity. Its main mechanism of action is to constrict blood vessels in the conjunctiva.

 

Items Specification
Appearance White to off-white

crystalline powder

Identification

A- IR spectrum

B-  UV spectrum

C- Reaction of chlorides

A.S.

A.S.

Positive

Heavy metals(USP)  NMT 0.005%
Loss on drying(USP) NMT1.0%
Residue on ignition NMT0.1%
Related substance-sum:

TLC(USP)

HPLC

NMT2.0%

NMT1.0%

Assay(in the dried substance): Titration(USP) 98.0%— 100.5%
Residuals solvents:

Methanol

Ethanol

Acetonitrile

Toluene

NMT3000ppm

NMT5000ppm

NMT410ppm

NMT890ppm

Conclusion It conform to the USP39

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