Active Pharmaceutical Ingredients Tetrahydrozoline hydrochloride
What is Tetrahydrozoline hydrochloride ?
Tetrahydrozoline Hydrochloride is the hydrochloride salt form of tetrahydrozoline, an imidazole derivative with sympathomimetic property. Applied locally to the eye or nose, tetrahydrozoline binds to and activates alpha-adrenergic receptors, resulting in vasoconstriction and decreased nasal and ophthalmic congestion.
Tetrahydrozoline hydrochloride is the hydrochloride salt of tetryzoline. It is used as a nasal decongestant. It has a role as a sympathomimetic agent, a vasoconstrictor agent and a nasal decongestant. It contains a tetryzoline
Tetrahydrozoline hydrochloride is a medication used to relieve redness in the eyes caused by minor eye irritations (such as smog, swimming, dust, or smoke). It works by narrowing swollen blood vessels in the eyes to reduce eye redness. It is also used as a decongestant for nasal congestion. Tetrahydrozoline hydrochloride is available in over-the-counter topical ocular and nasal formulations.
Product Description
Classification | Type | Tetrahydrozoline hydrochloride | |
CAS NO. | 522-48-5 | Other names | Tetrahydrozoline |
MF | C13H17CLN2 | EINECS NO. | 232-536-8 |
Place of origin | China | Grade standard | USP grade |
Purity | 99% | Appearance | White powder |
HS CODE | 2934990002 | packing | 25kg/drum |
Shelf life | 3 | MOQ | |
Application | RAw Material |
描述
Specification
Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity. Its main mechanism of action is to constrict blood vessels in the conjunctiva.
Items | Specification |
Appearance | White to off-white
crystalline powder |
Identification
A- IR spectrum B- UV spectrum C- Reaction of chlorides |
A.S.
A.S. Positive |
Heavy metals(USP) | NMT 0.005% |
Loss on drying(USP) | NMT1.0% |
Residue on ignition | NMT0.1% |
Related substance-sum:
TLC(USP) HPLC |
NMT2.0%
NMT1.0% |
Assay(in the dried substance): Titration(USP) | 98.0%— 100.5% |
Residuals solvents:
Methanol Ethanol Acetonitrile Toluene |
NMT3000ppm
NMT5000ppm NMT410ppm NMT890ppm |
Conclusion | It conform to the USP39 |