API Pharmaceutical Intermediates Raw Material Ketotifen Fumarate powder
What is Ketotifen Fumarate?
Ketotifen fumarate is a kind of strong anti-allergic drugs containing simultaneously of both tricyclic structure as well as piperidine structure. It is characterized by both a strong antagonism effect on histamine H1 receptor and inhibitory effect of the release of the mediator of allergic reaction.
Ketotifen Fumarate Description:
Product Name: Ketotifen Fumarate
Other Names: Ketotifen Fumarate
Type: Synthesis Material Intermediates
Appearance: white powder
MF: C23H23NO5S
CAS NO: 34580-14-8
EINECS NO: 252-100-0
Grade standard: ,Pharmaceutical grade
Shelf life: 2years
Packing: 25kg/drum
描述
What are the uses of Ketotifen Fumarate？
Ketotifen fumarate is a first-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis. In its oral form, it is used to prevent asthma attacks or Anaphylaxis, as well as various mast cell, allergic-type disorders.
Ketotifen Fumarate is a medication used to treat allergies and asthma. It works by blocking certain natural substances in the body that cause allergic symptoms. Ketotifen Fumarate is available in tablet and liquid form. Ketotifen Fumarate has many benefits. It can help to reduce symptoms of allergies and asthma quickly and effectively. It is also safe and easy to use with few side effects.
Ketotifen fumarate, also known as methylpheni date, thioperidone, sardiophenone, thiazoxide and ketotifol, is a potent anti-allergic drug with both a tricyclic and piperidine structure, characterized by strong antagonism of histamine H1 receptors and inhibition of the release of allergic response mediators. It inhibits the release of a variety of mediators from mast cells, basophils and macrophages, including slow-reacting substances and other reactive substances, has an antagonistic effect on calcium ions, inhibits phosphodiesterase and increases the cAMP content in mast cells. It inhibits chemotaxis and inflammatory response of neutrophils, which is 10 times stronger than paracetamol and has a long-lasting effect, stronger than sodium cromoglycate. Ketotifen fumarate has a therapeutic effect on both type I and type III metabolic reactions.
Ketotifen Fumarate Specification
| ITEM | STANDARD |
| Appearance | White |
| Solubility | conforms |
| Identification | conforms |
| Appearance of solution | conforms |
| ImpurityA | NMT0.2% |
| ImpurityG | NMT0.15% |
| Unspecified Impurity | NMT0.1% |
| Total Impurity | NMT0.3% |
| Loss on drying | NMT0.5% |
| Sulphated ash | NMT0.1% |
| Methanol | NMT3000ppm |
| Ethanol | NMT5000ppm |
| Acetone | NMT5000ppm |
| Tetrahydrofuran | NMT720ppm |
| Assay | 98.5%-101.0% |
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