Tobramycin

描述

Specification

Tobramycin is also known as tobramycin or nepaxin. One of the aminoglycoside antibiotics. Usually sulfate. The antibacterial spectrum is similar to that of gentamicin, but the antibacterial activity against Pseudomonas aeruginosa (PseudChemicalbookomonasaeruginosa) is 2 to 4 times stronger, and it is also effective against gentamicin-resistant strains; it is also effective against other G-bacteria. The antibacterial activity is slightly inferior to that of gentamicin. Can be used to treat a variety of serious infections caused by Pseudomonas aeruginosa and other G-bacteria.

Items	Specification
Appearance	White to off-white powder
Assay (on the anhydrous basis)	≥900μg/m
Residue on ignition	≤0.3%
Chromatographic purity(TLC	Any individual spot≤1.0%
PH	9.0 ~ 11.0
Water	≤7.5%
Specific optical rotation	+138°~ +148°
Clarity of solution	Clear, if the solution is turbid, it shall not exceed the turbidity of 0.5# turbidity standard solution
Colour	If colour develops, the colour of test solution should not be more intense than yellow or yellow-green 2# standard colour solution
Bacterial endotoxins	＜2.0EU/mg
Residual solvents	Ethanol                     ≤2000ppm Acetaldehyde                ≤450ppm
Microbial limit	TAMC                      ≤1000cfu/g TYMC                      ≤100cfu/g E.Coli               Should be absent/g
Conclusion	The product complies with USP and In-house Specifications